Biofilms are diverse communities of microorganisms (e.g. bacteria, fungi and yeasts) that embed themselves within a self-produced matrix and in doing so firmly attached themselves to one another and/or to surfaces. These surfaces may be biological (e.g. skin, wounds, teeth, or other body membranes), or not (e.g. implements, medical devices, furniture, or jewellery). The biofilm promotes the growth of the microorganisms, resulting in the thickening of the biofilm. In extreme cases, biofilms may appear as a “slime” to the naked eye.
Biofilms may harbour disease-causing organisms. According to one estimate, up to 80% of all microbial infections involve biofilm formation (1). If an infection develops a biofilm, it becomes even harder to treat. Biofilms are remarkably difficult to treat with antimicrobials, but the reasons for this are not clear. Antimicrobials may be inactivated or may fail to penetrate into the biofilm. In addition, bacteria within biofilms have increased (up to 1000-fold higher) resistance to antimicrobial compounds, and to the body’s defences (1, 2). Due to their embeddedness and resistance, biofilms often prove difficult to remove.
It has been suggested that skin biofilms may explain the chronic nature of many dermatological conditions, including atopic dermatitis, poor wound healing, acne, Candida infections, impetigo and boils (3).
N,N’-ethylenediaminetetraacetic acid — or EDTA for short — is an agent that binds up metal ions in solution. Because it holds to metal ions so tightly, it is also able to pull them away from their functions in biological molecules. In biofilms, metal ions are thought to be required for the creation of the microbial matrix and/or the adhesion within it — and so removing them with EDTA destroys the biofilm’s integrity.
In scientific studies, EDTA has been shown to be effective at removing microorganisms from a range of medically-relevant biofilms (4, 5, 6). This action has led to it being used to reduce infection risk in medical applications such as dialysis and device implantation, some wound dressings, and in dentistry (7, 8, 9, 10, 11).
Available without a prescription. Ask us about the dermatological preparations in which we have formulated EDTA. These products include lotions, gels, and foaming skin-wash products. These products are typically used twice daily.
Such products may be especially useful when used in conjunction with other skin preparations. For example, they may be applied as a cleanser before topical antibiotics for acne therapy.
An EDTA-containing wash may also boost the action of our Vitamin B3-containing preparations in reducing biofilm-feeding sebum secretions, reducing inflammation, and promoting healing.
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Can a compounding pharmacy help with migraines and headaches? Absolutely.
At Border Compounding pharmacy, our pharmacists can combine a number of ingredients and turn them into a gel that can be applied to the first 2 molars on the top gum. You can see from the diagram above this corresponds to the maxillary nerve. By telling this nerve to stop with the pain, you can get it to tell all the other ones in the trigeminal nerve meeting point to stop with the pain too.
The human skin microbiome has been established as being one of the master controls of dermal health. Most people are aware of the presence of ‘good’ and ‘bad’ bacteria, but there are other types of organisms present on healthy skin. The biome consists of bacteria, viruses, yeasts and mites.
The main form of mites on the skin are Demodex mites. They reside in the pores of the skin devouring sebum and other dead skin material. There are numerous strains of Demodex mites which vary according to the location they are found. In healthy skin at normal levels, demodex mites appear to release various substances known as immune reactive lipases, which may protect against S.Aureus and S.Pyogenes. Generally, demodex mites are innocuous and inconspicuous - even when their population is excessive. However, in the presence of increased lipid or sebum production or in instances of dermal immunosuppression, demodex mites flourish and start to release inflammatory chemicals. This is believed to be the basis for the inflammation and secondary bacterial infections associated with rosacea and perioral dermatitis.
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